Inhibition of Ultraviolet-induced Carcinogenesis by All-trans Retinoic Acid
نویسندگان
چکیده
منابع مشابه
Inhibition of ultraviolet-B skin carcinogenesis by all-trans-retinoic acid regimens that inhibit ornithine decarboxylase induction.
There is a correlation between the ability to induce the polyamine-biosynthetic enzyme ornithine decarboxylase (ODC) and the tumor-promoting ability of various carcinogens in mouse epidermis. Some agents which inhibit skin carcinogenesis also inhibit ODC induction. In this study, all-trans-retinoic acid (RA) regimens that inhibited the induction of epidermal ODC by ultraviolet-B (UVB) were test...
متن کاملAll Trans Retinoic Acid (ATRA) induced myositis.
A 5-year-old girl presented with fever, skin and mucosal bleeds, and pallor. Her hemoglobin was 3.6 g/dL, total white cell count 4.5×103/μL and platelet count 13×103/μL. Peripheral smear revealed 30% blasts, confirmed as APML on bone marrow examination. Cytogenetic analysis showed the typical translocation of t(15:17) with 77% of interphase cells expressing PML:RARA gene fusion. Child was start...
متن کاملAll-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.
Squamous cell carcinoma (SCC) of the skin is the most clinically aggressive form of nonmelanoma skin cancer. We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC. Stat3 is a transcription factor that plays a critical role in cell...
متن کاملAll-trans-retinoic acid: measurement
A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...
متن کاملAll-trans-retinoic acid-induced rhabdomyolysis: a case report
All-trans retinoic acid (ATRA) induced rhabdomyolysis in the induction treatment of acute promyelocytic leukemia (APL) is a very rare complication. However, rhabdomyolysis-related acute renal failure increases the risk of high morbidity and mortality. Here we describe a case of rhabdomyolysis associated with ATRA during the induction therapy in an adult with APL. Clinical implications are discu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1981
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12525686